Geben Sie die Zeichen unten ein Wir bitten um Ihr Direct compression aspirin tablets und wollen uns sicher sein dass Sie kein Bot sind. Sie können Ihre Anzeigeneinstellungen jederzeit ändern. METHODS USED FOR THE MANUFACTURE OF TABLETS Prepared By: DR.

Prof Department of pharmaceutics Lydia college of pharmacy Subject: Pharmaceutical Formulation Pharma. DEFINITION OF TABLETS A tablet is a pharmaceutical dosage form. It comprises of a mixture of active substances and excipients, usually in powder form, passed are compacted into a solid dose. Mixing of the therapeutic agents with the excipients 2.

It is most commonly used method for the manufacturing of tablets. Reduced segregation of formulation components during storage and processing. Leading to reduced intra and inter batch variability. It uses low concentration of therapeutic agent. The drug may be soluble in the granulation fluid. When tablet ingredients are sensitive to moisture and unable to withstand elevated temperature during drying and when the tablet ingredient have insufficient cohesive properties, slugging may be used to form granules. This technique popularity has decreased in recent years, having been superseded by direct compression.

However both slugging and roller compaction are still employed in tablet manufacture. Specialist equipment is required for granulation by roller compaction. Segregation of components may occur during post mixing. There may be issues regarding powder flow. Wet granulation and dry granulation methods having series of unit operations, both time consuming and potentially costly.

250, Dicalcium phosphate, Mannitol, Sorbitol, MCC. There are fewer processing steps and therefore the method is potentially more cost effective than other methods. Direct compression does not require the use of water or other solvents. The quality and uniformity of the final dosage form depends on the excipients.