Zusammenhänge zwischen regelmäßigem Zuckerkonsum und Anzeichen von Suchtverhalten thematisiert. Die Existenz einer Zuckersucht ist in der Naltrexone receptor umstritten.

Es existieren derzeit über 160 Studien, die einen Zusammenhang von Zuckerkonsum und Suchterscheinung untersuchen. So fand etwa eine Studie von Wissenschaftlern der Universität Princeton um Bart Hoebel 2008 heraus, dass im Laborexperiment Ratten bei regelmäßigem Zuckerkonsum Anzeichen einer Sucht zeigten. Hoebel: A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Hoebel: Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effect. Kehoe: Interactions between sucrose, pain and isolation distress.

Shah: Pain-reducing properties of sucrose in human newborns. Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence. Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain. Reid: Demonstrating morphine’s potentiating effects on sucrose-intake.

Kanarek: Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats. Marks-Kaufman: Duration of sucrose availability differentially alters morphine-induced analgesia in rats. Greenwood: Cream and sugar: human preferences for high-fat foods. Taste responses and preferences for sweet high-fat foods: evidence for opioid involvement. Naloxone, an opiate blocker, reduces the consumption of sweet high-fat foods in obese and lean female binge eaters.

Sweets release opiates which stimulates the appetite for sucrose—insulin can depress it. Apfelbaum: An opioid antagonist, naltrexone, reduces preference for sucrose in humans. Sweet preference predicts mood altering effect of and impaired control over eating sweet foods. Wiatr: Chronic sucrose intake augments antinociception induced by injections of mu but not kappa opioid receptor agonists into the periaqueductal gray matter in male and female rats. Butter: Pleasantness of a sweet taste during hunger and satiety: effects of gender and “sweet tooth”.